The heating of response site 1 permits the dissimilar oligonucleotides 56 to be cleaned away150 (step h). Thermally aided reagent treatment of site 1 cleaves safety and visite site security catch linkers and launches the preferred duplex DNA 57 from the chip29,151 (action i). This Web-site liberated DNA is annealed to a chip-bound corresponding DNA duplex 58...